It’s that time of the year again. St. Jude’s Children’s Research Hospital and Jennifer, alongside Robin Williams, Morgan Freeman, George Lopez, Shaun White, Dwyane Wade, singer Luis Fonsi and St. Jude National Outreach Director Marlo Thomas, are teaming up with the patients of St. Jude to tell us about their mission of saving these adorable children.

Check out the trailer and look forward to a special TV spot with Jennifer and Hayli, which is supposed to debut on November 22.